个人简介
嵇豪男，博士，讲师，硕士生导师，籍贯江苏阜宁。毕业于江南大学发酵工程专业，获工学博士学位。科研方向为微生物资源开发与应用，重点关注微生物重要代谢产物的代谢调控、分离纯化及其功能化。先后主持和参与多项国家级及省部级项目。在Laboratory Investigation、Materials Today Bio、Frontiers in Pharmacology和Journal of Fungi等学术期刊发表学术论文20余篇，获授权发明专利6项。
主要研究方向
微生物资源开发与应用、微生物重要代谢产物的功能化。
发表论文
1.Advancesin Escherichia coliNissle 1917 as a customizable drug delivery system for disease treatment and diagnosis strategies. Mater Today Bio. 2023, 18:100543.
2.Advances in the Application of the Non-Conventional YeastPichia kudriavzeviiin Food and Biotechnology Industries. J. Fungi 2023, 9, 170.
3.Bioglass promotes wound healing by inhibiting endothelial cell pyroptosis through regulation of the connexin 43/reactive oxygen species (ROS) signaling pathway. Lab Invest. 2022,102(1):90-101
4.Toxic Mechanism and Biological Detoxification of Fumonisins, Toxins, 2022.3.1, 14(3), 182.
5.Sequential Production of D-xylonate and Ethanol from Non-Detoxified Corncob at Low-pH byPichia kudriavzeviivia a Two-Stage Fermentation Strategy, Journal of Fungi, 2021, 7(12): 0-1038
6.Recent Advances in ROS-Sensitive Nano-Formulations for Atherosclerosis Applications. Pharmaceutics. 2021, 11;13(9):1452.
7.Dl-3-n-Butylphthalide Ameliorates Diabetic Nephropathy by Ameliorating Excessive Fibrosis and Podocyte Apoptosis. Front Pharmacol. 2021, 23;12:628950
8.Bacterial Ghosts-Based Vaccine and Drug Delivery Systems, Pharmaceutics, 2021.11.2. 13(11), 1892.
9.Advances in the Relationship Between Pyroptosis and Diabetic Neuropathy. Front Cell Dev Biol. 2021,12;9:753660.
10.Transcriptional profiling reveals molecular basis and the role of arginine in response to low-pH stress inPichia kudriavzevii, Journal of Bioscience and Bioengineering, 2020, 130(6): 588-595
11.Macrophage-based therapies for atherosclerosis management, Journal of Immunology Research, 2020, 23(6093): 1-11.
12.Topical Application of Fibroblast Growth Factor 10-PLGA Microsphere Accelerates Wound Healing via Inhibition of ER Stress. Oxid Med Cell Longev. 2020, 5;2020:8586314.
13.Ethanol fermentation from non-detoxified lignocellulose hydrolysate by a multi-stress tolerant yeastCandida glycerinogenesmutant. Bioresource Technology, 2019, 273:634-640.
14.产甘油假丝酵母HOG途径应答研究进展[J].中国科学:生命科学,2019,49(05):585-594.
15.Functional and expression studies of two novel STL1 genes of the osmotolerant and glycerol utilization yeastCandida glycerinogenes. J Gen Appl Microbiol. 2018 Jul 23;64(3):121-126
16.γ-aminobutyric acid accumulation enhances the cell growth ofCandida glycerinogenesunder hyperosmotic conditions. J. Gen. Appl. Microbiol, 2018 May 21;64(2):84-89.
17.Gene expression profiles ofCandida glycerinogenesunder combined heat and high-glucose stresses. J Biosci Bioeng. 2018, 30. pii: S1389-1723(18)30017-3.
18.A synthetic hybrid promoter for D-xylonate production at low pH in the tolerant yeastCandida glycerinogenes, Bioengineered, 2017, 8(6): 700~706
19.Role of CgHOG1 in stress responses and glycerol overproduction ofCandida glycerinogenes. Current Microbiology, 2016, 73(6): 827~833
20.Bioconversion of L-phenylalanine to 2-phenylethanol by the novel stress-tolerant yeastCandida glycerinogenesWL2002-5, Bioengineered, 2016, 7(6): 418~423.
21.Identification of a novel HOG1 homologue from an industrial glycerol producerCandida glycerinogenes. Current Microbiology, 2014, 69 (6): 909~914
22.Antimicrobial compound from a novelStreptomyces termitumstrain ATC-2 againstXanthomonas oryzaepv.Oryzae. Research journal of biotechnology, 2013.7.1, 8(7): 66~70
23.Optimization of Fermentation parameters on T-DNA insertedMonascus purpureusmutant MT24 with high pigments production capacity. Research Journal of Biotechnology, 2012, 7(2): 9~13
科研课题
1. 浙江省自然科学基金探索项目Q，LQ20C200015，极端酸性压力诱导库德毕赤酵母细胞形态发生的分子机制研究
2. 温州市基础性科研项目，2018G0178，多耐受酵母Pichia kudriavzevii低pH发酵生产D-木糖酸的关键技术研究
3. 国家自然科学基金面上项目，31972418，白菜花粉响应低温胁迫的lncRNA-BrCBF4-COR基因调控通路研究
4. 国家自然科学基金面上项目，31570052，耐超高渗工业酵母的CgHOG 途径及其抗逆性应答转录调节研究
5. 国家自然科学基金面上项目，31270061，紫色红曲菌色素和桔霉素合成关键基因的克隆及表达调控
6. 国家自然科学基金面上项目，31070008，红曲菌γ-氨基丁酸代谢相关基因（gabaX）的克隆、鉴定和功能分析
7. 国家自然科学基金青年基金项目，21002092，白蚁共生放线菌的抗菌成分研究
8. 浙江省自然科学基金探索项目，Y21C150007，长链非编码RNA lncBrCPL3在白菜花粉低温应答中的功能研究
9. 浙江省自然科学基金探索项目，Y2100757，白蚁共生放线菌的抗菌成分及其构效关系研究
授权发明专利
1.抑制库德毕赤酵母菌株细胞聚集的方法、构建和应用. CN202010522228.2
2.一种过表达产甘油假丝酵母CgGAD1提高渗透压耐受性的方法. CN201711232385.4
3.用于促进伤口愈合的药物及方法. CN202011612639.7
4.一种弧度高度可调的扁平足矫正鞋垫. CN202010769845.2
5.高产灵菌红素的粘质沙雷氏菌(Serratia marcescens)Sm-128菌株及其应用. CN201110225762.8
6.高产红曲色素紫色红曲霉Mp-41菌株及其应用. CN200910102278.9
承担的主要课程
制药设备与工艺设计、生物技术制药实验
联系电话18367803306
电子邮箱20180031@wzu.edu.cn
