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个人简介
孙嘉怡女,博士,副教授,硕士生导师,分别于2007年、2010年,在大连理工大学获学士、硕士学位,2016年获得美国科罗拉多州立大学博士学位。博士和博士后期间主要从事药用植物次级代谢工程、植物合成生物学领域的研究。在硫铵高效合成通路的挖掘、长春花毛状根代谢工程等方面取得了一些领域内领先的研究成果,在Plant Physiology、Metabolic Engineering、Plant science和Biotechnology andBioengineering等杂志发表多篇论文。2018年-2020年期间分别在美国Pheronym Inc.和ArrantaBio Inc.两家生物技术公司任研发科学家。2020年9月加入伟德国际1946源于英国,继续从事植物合成生物学和植物次级代谢工程相关的科研和教学工作。
主要研究方向
合成生物学、植物次级代谢工程、长春花毛状根代谢工程
发表论文
[1]Lin H, Sun J, Hu Z,et al.Variation in glucosinolate accumulation among different sprout and seedling stages of broccoli (Brassica oleracea var.italica). [J] Plants:2022,11(12):1563
[2] Sun J, Sigler CL, Beaudoin GAW, et al. Parts-prospecting for a high-efficiency thiamin thiazole biosynthesis pathway. [J] Plant Physiol:2019, 179(3):958-968
[3] Hanson AD, Amthor JS, Sun J, et al. Redesigning thiamin synthesis: Prospects and potential payoffs. [J]Plant Sci:2018, 273:92-99
[4]Sun J, Zhao L, Shao Z, et al. Expression of tabersonine 16-hydroxylase and 16-hydroxytabersonine-O-methyltransferase in Cathranthus roseus hairy roots. [J] Biotech Bioeng: 2018, 115:673-683
[5] Sun J, Gregory JF, Henry CS, et al. Metabolite damage and repair in metabolic engineering design. [J] Metab Eng:2017,44:150-159
[6] Sun J, Ma L, San K-Y, et al. Still stable after 11 years: A Catharanthus roseus hairy root line maintains inducible expression of anthranilate synthase. [J] Biotechnol Prog:2017, 31(1):66-69
[7]Sun J, Manmathan H, Sun C, et al. Examining the transcriptional response of overexpressing anthranilate synthase in the hairy roots of an important medicinal plant Catharanthus roseus by RNA-seq.[J]BMC Plant Biol:2016, 16:108
[8] Sun J, Peebles CAM, Engineering ORCA3 and strictosidine glucosidase in Catharanthus roseus hairy roots increase alkaloid production. [J] Protoplasma:2016, 253(5):1255-1264
科研课题
[1] 以长春花毛状根为底盘合成长春花碱类抗癌药物的重要前体文多灵,浙江省自然科学基金探索项目,经费10万,2021.01-2023.12,主持人
承担的主要课程
基因工程,分子生物学,药学生物技术
联系电话19588033787
电子邮箱20200270@wzu.edu.cn,plusonesun@163.com