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个人简介
佟海滨,伟德国际1946源于英国,硕导,瓯江特聘教授。毕业于东北师范大学细胞生物学博士(导师:曾宪录教授),中国中医科学院中药学博士后(合作导师:黄璐琦院士),美国耶鲁大学医学院访问学者(合作导师:Martin Schwartz教授)。
主持国家自然科学基金面上项目、青年基金、吉林省科技厅重点科技攻关项目、浙江省自然科学基金面上项目、中国博士后科学基金面上资助、温州市科技局重大科技创新攻关项目等。以第一及通讯作者身份发表SCI论文70余篇,h指数23(Google Scholar)。获得省自然科学二等奖1项,科技进步二等奖2项,2016年获得“吉林省青年科技奖”。
课题组重点开展干预治疗急慢性炎症、代谢性疾病新型先导化合物的发现,挖掘新靶点新机制。
学术任职:
浙江省生物化学与分子生物学学会 理事
浙江省药学会海洋药物专业委员会 委员
浙江省药学会中药与天然药物专业委员会 委员
中国药理学会海洋药物药理专业委员会 青年委员
Frontiers in Marine Science(IF: 5.247,中科院2区Top)客座编辑
International Journal of Molecular Sciences (IF:6.208,中科院2区Top)客座编辑
Frontiers in Pharmacology(IF:5.8,中科院2区)客座编辑
主持的科研项目:
1.羊栖菜岩藻聚糖硫酸酯干预高脂高糖膳食诱导胰岛素抵抗的功效评价及新型糖类先导物的发现,温州市重大科技创新攻关医疗卫生项目,项目编号:ZY2019013,起止日期:2020.01至2021.12,经费:70万,项目负责人。
2.柴胡中基于P-selectin靶点治疗急性肺损伤的新型糖类先导化合物的发现与作用机制研究,国家自然科学基金面上项目,项目编号:81872952,起止日期:2019.01至2022.12,经费:56万,项目负责人。
3.羊栖菜多糖功能性糖链基序基于P-selectin靶点发挥急性肺损伤保护作用的机制研究,浙江省自然科学基金面上项目,项目编号:LY18C020006,起止日期:2018.01至2020.12,经费:10万,项目负责人。
4.柴胡多糖拮抗P-选择素发挥急性肺损伤保护作用的研究,中国博士后科学基金第61批面上资助一等,项目编号:2017M610155,起止日期:2017.04至2018.08,经费:8万,项目负责人。
5. c-Abl激酶在中性粒细胞应答剪切力爬行进程中的分子行为及作用机制研究,国家自然科学基金青年项目,项目编号:31401203,起止日期:2015.01至2017.12,经费:25万,项目负责人。
6.基于P-selectin功能拮抗的柴胡多糖核心糖链基序的纯化及新型糖类抗炎药物开发,吉林省科技厅重点科技攻关项目,项目编号:20140204039YY,起止日期:2014.01至2016.12,经费:15万,项目负责人。
获奖情况:
1.吉林省青年科技奖
2.中国商业联合会科学技术奖,三等奖,2020,第一完成人
3.浙江省药学会科学技术奖,二等奖,2020,第一完成人
4.吉林省自然科学奖,二等奖,2019,第二完成人
5.吉林省自然科学奖,二等奖,2015,第二完成人
6.吉林省科技进步奖,二等奖,2013,第二完成人
近五年以通讯作者身份发表SCI论文(#同等贡献;*通讯作者):
2023年
1. Jiang, P., Ji, X., Xia, J., Xu, M.R., Hao, F., Tong, H.B.*, Jiao, L.L.* Structure and potential anti-fatigue mechanism of polysaccharides from Bupleurum chinense DC. Carbohydrate Polymers, 2023, 306, 120608 (IF:10. 723,1区 Top)
2.Hu, Y.X., Wu, H.J., Lu, C.Y., Xu, H.Q., Li, B.Y., Guan, W.C., Wu, M.J., Gao, Y.T.*, Tong, H.B.* Cadmium chloride exposure impairs the growth and behavior of Drosophila via ferroptosis. Science of The Total Environment, 2023, 865, 161183(IF:10. 753,1区 Top)
3. Wu, Y., Jin, X.S., Zhang, Y., Liu, J., Wu, M.J.*, Tong, H.B.* Bioactive compounds from brown algae alleviate non-alcoholic fatty liver disease: An extensive review. Journal of Agricultural and Food Chemistry, 2023, 71, 1771–1787.(IF:5.895,1区Top)
2022年
4. Zhang, Y.#, Cheng, Y.#, Liu, J.#, Zuo, JH., Yan, L.P., Thring, W.R., Ba, X.Q., Qi, D.K., Wu, M.J., Gao, Y.T.*, Tong, H.B.* Tauroursodeoxycholic acid functions as a critical effector mediating insulin sensitization of metformin in obese mice. Redox Biology, 2022 , 57, 102481(IF:10.787,1区 Top)
5. Zuo, J.H.#, Zhang, Y.#, Wu, Y.#, Liu, J., Wu, Q.F., Shen, Y.Z., Jin, L., Wu, M.J.*, Ma, Z.L.*, Tong, H.B.* Sargassum fusiforme fucoidan ameliorates diet-induced obesity through enhancing thermogenesis of adipose tissues and modulating gut microbiota. International Journal of Biological Macromolecules, 2022, 216, 728–740 (IF:8.025,1区Top)
6. Zhang, Y.#, Wu, Q.F.#, Liu, J., Zhang, Z.S., Ma, X.J., Zhang, Y.Y., Zhu, J.W., Thring, W.R., Wu, M.J., Gao, Y.T.*, Tong, H.B.* Sulforaphane alleviates high fat diet-induced insulin resistance via AMPK/Nrf2/GPx4 axis. Biomedicine & Pharmacotherapy, 2022, 152, 113273(IF:7.419,1区 Top)
7. Wu, S.Y.#, Liu, J.#, Zhang, Y.#, Song, J.X., Zhang, Z.S., Yang, Y., Wu, M.J.*, Tong, H.B.* Structural characterization and antagonistic effect against P-selectin-mediated function of SFF-32, a fucoidan fraction from Sargassum fusiforme. Journal of Ethnopharmacology, 2022, 295, 115408(IF:5.195,1区 Top)
8. He, D.#, Wu, Q.F.#, Lu, C.Y., Wu, J.L., Chen, P.C., Wu, M.J.*, Choi, J.I.*, Tong, H.B.* Pyropia yezoensis porphyran alleviates metabolic disorders via modulating gut microbiota in high sucrose-fed Drosophila melanogaster. Journal of The Science of Food and Agriculture, 2022, 102, 4802-4812(IF:4.125,2区 Top)
9. Qin, Z.Y., Yuan, X.Y., Liu, J., Shi, Z.Q., Cao, L.P., Yang, L.X., Wu, K., Lou, Y.L, Tong, H.B.*, Jiang, L.*, Du, J.M.* Albuca Bracteata polysaccharides attenuate AOM/DSS induced colon tumorigenesis via regulating oxidative stress, inflammation and gut microbiota in mice. Frontiers in Pharmacology, 2022, 13:833077(IF:5.988,2区Top)
2021年
10.Zhang, Y.#, Liu, J.#, Mao, G.X.#, Zuo, J.H. Li, S.J., Yang, Y., Thring, R., Wu, M.J.*, Tong, H.B.* Sargassum fusiforme fucoidan alleviates diet-induced insulin resistance by inhibiting colon-derived ceramide biosynthesis. Food & Function, 2021, 12, 8440–8453.(IF:6.317,1区Top)
11. Liu, J.#, Wu, S.Y.#, Cheng, Y.#, Liu, Q., Su, L.J., Yang, Y., Zhang, X., Wu, M.J., Choi, J.-i.*, Tong, H.B.* Sargassum fusiforme alginate relieves hyperglycemia and modulates intestinal microbiota and metabolites in type 2 diabetic mice. Nutrients, 2021, 13, 2887.(IF:6.706,2区Top)
12. Wu, Q.F., Du, X.T., Feng, X.C., Cheng, H.M., Chen, Y.J., Lu, C.Y., Wu, M.J., Tong, H.B.* Chlordane exposure causes developmental delay and metabolic disorders in Drosophila melanogaster. Ecotoxicology and Environmental Safety, 2021, 225, 112739.(IF:7.129,2区Top)
13. Wu, S.Y.#, Zuo, J.H.#, Cheng, Y.#, Zhang, Y., Zhang, Z.S., Wu, M.J.*, Yang, Y.*, Tong, H.B.* Ethanol extract of Sargarsum fusiforme alleviates HFD/STZ-induced hyperglycemia in association with modulation of gut microbiota and intestinal metabolites in type 2 diabetic mice. Food Research International, 2021, 147, 110550.(IF:7.425,1区Top)
14. Wu, Q.F. #, Wu, S.Y. #, Cheng, Y. #, Zhang, Z.S., Mao, G.X., Li, S.J., Yang, Y., Zhang, X., Wu, M.J.*, Tong, H.B.* Sargassum fusiforme fucoidan modifies gut microbiota and intestinal metabolites during alleviation of hyperglycemia in type 2 diabetic mice. Food & Function, 2021, 12, 3572–3585.(IF:6.317,1区Top)
15. He, D., Yan L.P., Hu, Y.X., Wu, Q.F., Wu, M.J.*, Choi, J.I.*, Tong, H.B.* Optimization of Pyropia yezoensis porphyran by response surface methodology and its lipid-lowering effect. Marine Drugs, 2021, 19, E53.(IF:5.118,2区)
2020年
16.Song, J.X., Wu, Y., Ma, X.J., Feng, L.J., Wang, Z.G., Jiang, G.Q.*, Tong, H.B.* Structural characterization and α-glycosidase inhibitory activity of a novel polysaccharide fraction from Aconitum coreanum. Carbohydrate Polymers, 2020, 230, 115586.(IF:10.723,1区Top)
17.Zhang, Y.#, Zuo, J.H.#, Yan, L.P.#, Cheng, Y., Li, Q.J., Wu, S.Y., Chen, L., Thring, R., Yang, Y., Gao, Y.T.*, Wu, M.J.*, Tong, H.B.* Sargassum fusiforme fucoidan alleviates high-fat diet-induced obesity and insulin resistance associated with the improvement of hepatic oxidative stress and gut microbiota profile. Journal of Agricultural and Food Chemistry, 2020, 68, 10626–10638.(IF:5.895,1区Top)
18. Liu, J.#, Wu, S.Y.#, Chen, L., Li, Q.J., Shen, Y.Z., Jin, L., Zhang, X., Chen, P.C., Wu, M.J.*, Choi, J.I*, Tong, H.B.* Different extraction methods bring about distinct physicochemical properties and antioxidant activities of Sargassum fusiforme fucoidans. International Journal of Biological Macromolecules, 2020, 155, 1385–1392. (IF:8.025,1区Top)
2019年
19. Luthuli, S.#, Wu, S.Y.#, Cheng, Y., Zheng, X.L., Wu, M.J.*, Tong, H.B.* Therapeutic effects of fucoidan: A review on recent studies. Marine Drugs, 2019, 17, E487.(IF:5.118,2区,入选高被引论文)
20.Song, J.X., Wu, Y., Jiang, G.Q., Feng, L.J., Wang, Z.G., Yuan, G.X.*, Tong, H.B.* Sulfated polysaccharides from Rhodiola sachalinensis reduce D-gal-induced oxidative stress in NIH 3T3 cells. International Journal of Biological Macromolecules, 2019, 140, 288–293. (IF:8.025,1区Top)
21.He, D.#, Wu, S.Y.#, Yan, L.P., Zuo, J.H., Cheng, Y., Wang, H.F., Liu, J., Zhang, X., Choi, J.I., Wu, M.J.*, Tong, H.B.* Antitumor bioactivity of porphyran extracted from Pyropia yezoensis Chonsoo2 on human cancer cell lines. Journal of the Science of Food and Agriculture, 2019, 99: 6722–6730. (IF:4.125,2区 Top)
22. Cheng, Y.#, Sibusiso, L.#, Hou, L.F., Jiang, H.J., Chen, P.C., Zhang, X., Wu, M.J.*, Tong, H.B.* Sargassum fusiforme fucoidan modifies the gut microbiota during alleviation of streptozotocin-induced hyperglycemia in mice. International Journal of Biological Macromolecules, 2019, 131: 1162-1170. (IF:8.025,1区Top)
23. Wu, S.Y., Zhang, X., Liu, J., Song, J.X., Yu, P., Chen, P.C., Liao, Z.Y., Wu, M.J.*, Tong, H.B.* Physicochemical characterization of Sargassum fusiforme fucoidan fractions and their antagonistic effect against P-selectin-mediated cell adhesion. International Journal of Biological Macromolecules, 2019, 133: 656-662. (IF:8.025,1区Top)
联系方式:
温州市茶山高教园区 伟德国际1946源于英国10B409
电话:13819706331
Email:tonghaibin@gmail.com;tonghb@wzu.edu.cn
课题组主页:https://www.x-mol.com/groups/tong_haibin
ResearchGate:https://www.researchgate.net/profile/Haibin_Tong
谷歌学术:https://scholar.google.com/citations?user=2ePT8IMAAAAJ&hl=zh-CN