姓名：许诺 性别：男
学历：博士 民族：汉
E-Mail: 20160125@wzu.edu.cn
联系号码：86-15957719656
通讯地址：浙江省温州市茶山高教园区伟德国际1946源于英国10B-405
个人简介：
共产党员，副教授，就职于伟德国际1946源于英国，生物制药专业负责人，硕士研究生导师。吉林大学微生物与生化药学专业博士。
主要研究方向：
1. 原核/植物生物反应器药用蛋白的制备与纯化研究
2. 成纤维细胞因子（FGFs）与皮肤病理生理研究
3. 功能性护肤产品的药效评测与研发
学习经历：
博士(Ph.D) 2012.09-2016.06，吉林大学，微生物与生化药学，导师，李校堃 院士
硕士(Master) 2009.09-2012.06，吉林农业大学，遗传育种，导师，王丕武 教授
学士(Bachelor) 2004.08-2008.06，吉林农业大学，生物工程
v 主持或参加的主要科研项目：
1. 国家自然科学基金青年项目，81903736，燕麦β-葡聚糖作用于Dectin-1调控表皮屏障损伤修复的机制研究，2020.01-2022.12，21万，结题，主持；
2. 浙江省药学重中之重一级学科开放基金，201722，人源EGF的植物表达研究及高表达植株的获得，2017.07-2019.12，6万，结题，主持；
3. 温州市基础性科研项目，N20180002，紫花苜蓿MsWRKY19基因在铬胁迫下的分子机制解析，2019.01-2020.12，3万，结题，主持；
4. 瓯海区重点科研项目，2024oh0002， 化妆品植物新原料的创制及其功效评测建立的研究，2025.01-2027.12，30万，在研，参与；
5. 理科横向课题，2021-126K，保湿成分促进皮肤线粒体水分生成的功效评价及新机制研究，2021.12-2023.12，140万，结题，主持；
6. 理科横向课题，2020-020K，复合多糖缓解萃白因子不适反应的功效验证及机理研究，2020.06-2021.09，148万，结题，主持；
7. 理科横向课题，2021-076K，复合多糖缓解萃白因子不适应反应的功效验证及机理研究补充实验，2021.09-2022.06，30万，结题，主持；
8. 理科横向课题，2018-100K，市场防脱生发活性物梳理及“RNA干扰”防脱生发技术初步研究， 2018.01-2020.12,50万，结题，主持；
主要文章：
(1) Xuenan Li, Jinli Cheng, keke Guo, Jianwei Wan, Cuihong Wang, Lu Chen, Nuo Xu*, Min Chen. KGF-2 ameliorates UVB-triggered skin photodamage in mice by attenuating DNA damage and inflammatory response and mitochondrial dysfunction, Photodermatology Photoimmunology & Photomedicine, 2024, 40(5): e12993.(IF: 2.5)
(2) Guangdong Yu, Wengang Zhao, Yunpeng Wang, Nuo Xu*. Molecular farming expression of recombinant fusion proteins applied to skincare strategies, Peer J, 2024, 12: e17957.(IF: 2.8)
(3) Keke Guo, Lusheng Wang, Yulan Zhong, Shuang Gao, Rongrong Jing, Jiabin Ye, Kaini Zhang1, Mengli Fu, Zhenlin Hu, Wengang Zhao, Nuo Xu*. Cucurbitacin promotes hair growth in mice by inhibiting the expression of fibroblast growth factor 18, Annals of Translational Medicine, 2022, 10(20):1104. (IF: 3.9)
(4) Shuang Gao, Yu Chen, Jungang Zhao, Rongrong Jing, Keke Guo, Lusheng Wang,Xuenan Li, Chengliang Li, Zhenlin Hu, Nuo Xu*. Oat β-glucan ameliorates epidermal barrier disruption by upregulating the expression of CaSR through dectin-1-mediated ERK and p38 signaling pathways, International Journal of Biological Macromolecules, 2021, 185(7): 876-889. (IF: 8.0)
(5) Shuang Gao, Keke Guo, Yu Chen, Jungang Zhao, Rongrong Jing, Lusheng Wang, Xuenan Li, Zhenlin Hu, Nuo Xu* and Xiaokun Li. Keratinocyte Growth Factor 2 Ameliorates UVB-Induced Skin Damage via Activating the AhR/Nrf2 Signaling Pathway, Frontiers in Pharmacology, 2021, Jun 7:12:655281. (IF: 5.81)
(6) Rongrong Jing, Keke Guo, Yulan Zhong, Lusheng Wang, Jungang Zhao, Bingyan Gao, Ziyi Ye, Yu Chen, Xuenan Li, Nuo Xu*. Protective effects of fucoidan purified from Undaria pinnatifida against UV-irradiated skin photoaging, Annals of Translational Medicine, 2021, 9(14):1185. (IF: 3.9)
(7) Jungang Zhao , Haojie Lin , Lusheng Wang , Keke Guo , Rongrong Jing , Xuenan Li , Yu Chen , Zhenlin Hu , Shuang Gao * and Nuo Xu *.Suppression of FGF5 and FGF18 Expression by Cholesterol-Modified siRNAs Promotes Hair Growth in Mice, Frontiers in Pharmacology, 2021, 7:12:666860. (IF: 5.81)
(6) Xuenan Li, Kaiye Yang, Shuang Gao, Jungang Zhao, Guangrong Liu, Yu Chen, Haojie Lin, Wengang Zhao, Zhenlin Hu and Nuo Xu* Carnosine Stimulates Macrophage-Mediated Clearance of Senescent Skin Cells Through Activation of the AKT2 Signaling Pathway by CD36 and RAGE, Frontiers in Pharmacology, 2020, 16:11:593832. (IF: 5.81)
(7) Yu Chen, Junmei Qi, Xiaoshuang Gan, Nuo Xu*, Zhenlin Hu*. Fucoidan from Undaria pinnatifida Ameliorates Epidermal Barrier Disruption via Keratinocyte Differentiation and CaSR Level Regulation, Mar. Drugs, 2019, 17(12): E660. (IF: 3.77)
(8) Lusheng Wang, Rongrong Jing, Xing Wang, Baohui Wang, Keke Guo, Jungang Zhao, Shuang Gao, Nuo Xu*, Xuan Xuan*. A method for the expression of fibroblast growth factor 14 and assessment of its neuroprotective effect in an Alzheimer’s disease model, Annals of Translational Medicine, 2021, 9(12):994. (IF: 3.9)
(9) Nuo Xu, Baohui Wang, Qianyun Zhou, Yuehong Ouyang, Weiyue Gong, Haishan Tian, Xiaokun Li, Chao Jiang. Expression of Halo-hFGF18 and study of its effect on differentiation of ATDC5 cells, Protein Expression and Purification, 2019,155(3): 8-14. (IF: 1.338)
(10) Nuo Xu, Wenjuan Deng, Gaiying He, Xiaoshuang Gan, Shuang Gao, Yu Chen, Yitian Gao, Ke Xu, Junmei Qi, Haojie Lin, Li Shen, Xiaokun Li, Zhenlin Hu. Alpha- and gamma-mangostins exhibit anti-acne activities via multiple mechanisms, Immunopharmacology and Immunotoxicology, 2018,40 (5): 415-422. (IF: 1.209)
(11) Feng Zhai, Nuo Xu, Jing Yang, Yunpeng Wang, Libo Jin, Haiyan Li, Xiaokun Li, Chao Jiang. Expression of human FGF18 by fusion with oleosin in Arabidopsis thaliana seeds, Journal of Plant Biology, 2018,14(5):1-8. (IF: 2.9)
(12) Nuo Xu, Yunpeng Wang, Jisheng Ma, Libo Jin, Shaochen Xing, Chao Jiang and Xiaokun Li. Over-expression of fHbp in Arabidopsis for development of meningococcal serogroup B subunit vaccine, Biotechnology Journal, 2016,11(7): 973-980. (IF: 4.7)
(13) 刘光荣，赵俊钢，邓文娟，胡振林，李成亮，许诺*. 橙皮苷的抗痤疮作用研究. 日用化学品科学，2020，3（43）：42-46。
专利：
1. 许诺，胡振林，李校堃，高爽，李世军，王云鹏，王宝慧，丁明，祁均梅，林豪杰，陈毓，李雪囡，一种脑膜炎球菌fHbp蛋白的表达系统，2022.04.19，中国，ZL201811425674.0
2. 高爽，许诺，李校堃，胡振林，陈毓，赵文刚，靶向FGF5的siRNA在治疗脱发中的应用，2022.1.11，中国，ZL202010996869.1
