个人简介

高艺恬 女，1989年9月，博士，青年硕士生导师。2007年至2014年就读于沈阳药科大学，获得学士和硕士学位，2017年9月毕业于英国贝尔法斯特女王大学（药学），获得博士学位。目前研究方向：天然及基于靶点设计的活性多肽的抗菌及抗炎活性和机制研究。

主要研究领域

1.天然抗菌肽的发现及改造。

2.肽类药物的研究与开发

研究经历

2014.09–2017.07

博士（药物生物技术）英国贝尔法斯特女王大学，药学院

2011.09–2014.06

硕士（药物分析）沈阳药科大学，药学院

导师：赵春杰教授

2007.09–2011.07

学士（药学）沈阳药科大学，药学院

代表性荣誉

1.英国贝尔法斯特女王大学优秀博士奖学金，2015，2016

2.温州市海外精英引进计划-创新长期项目人才，2018

3.浙江省高校青年优秀人才培养计划，2020

主持国家级课题

靶向优化的新型抗菌肽MS-PT1a抗耐甲氧西林金黄色葡萄球菌的作用与机制研究，资助类别：青年科学基金项目，81803590，主持，在研。2019.01,01-2021.12.31，21万

发表论文

1.Song, X., Pan, H., Wang, H., Liao, X., Sun, D., Xu, K., Chen, T., Zhang, X., Wu M., Wu, D., Gao, Y. (2020)Identification of new dermaseptins with self-assembly tendency: membrane disruption, biofilm eradication, and infected wound healing efficacy. Acta Biomaterialia, 6642. (IF=7.242)

2.Wu, D., Gao, T., Tan, Y., Liu, Y., Wang, L., Zhou. M., Xi. X., Ma, C., Olaf, R.P., Chen, T., Chaw, C.., (2018) Discovery of Distinctin-Like-Peptide-PH (DLP-PH) From the Skin Secretion of Phyllomedusa hypochondrialis, a Prototype of a Novel Family of Antimicrobial Peptide. Frontiers in Microbiology, 9:541. (IF=4.076)

3.Gao, Y., Wu, D., Wang, L., Chen, L., Ma, C., Xi, X., Zhou, M., Duan, J., Olaf, R, P., Chen, T. and Shaw, C., (2017) Targeted modification of a novel amphibian antimicrobial peptide from Phyllomedusa tarsius to enhance its activity against MRSA and microbial biofilm. Frontiers in microbiology 8: 628 (IF=4.076).

4.Gao, Y., Wu, D., Xi, X., Wu, Y., Ma, C., Zhou, M., Wang, L., Yang, M., Chen, T. and Shaw, C., (2016) Identification and characterisation of the antimicrobial peptide, Phylloseptin-PT, from the skin secretion of Phyllomedusa tarsius, and comparison of activity with designed, cationicityenhanced analogues and diastereomers. Molecules, 21: 1667 (IF=2.861).

5.Wu, D.,Gao, Y., Wang, L., Xi, X., Wu, Y., Zhou, M., Zhang, Y., Ma, C., Chen, T. and Shaw, C., (2016), A combined molecular cloning and mass spectrometric method to identify, characterize, and design Frenatin peptides from the skin secretion of Litoria infrafrenata. Molecules, 21:1429. (equal contribution, IF=2.861).

6.Shi, D., Hou, X., Wang, L.,Gao, Y., Wu, D., Xi, X., Zhou, M., Kwok, H., Duan, J., Chen, T. et al.,(2016), Two novel Dermaseptin-like antimicrobial peptides with anticancer activities from the skin secretion of Pachymedusa dacnicolor.Toxins.8: 144 (IF=3.030).

7.Shi, D., Xi, X., Wang, L.,Gao, Y., Ma, C., Chen, H., Zhou, M., Chen, T. and Shaw, C., (2016), Baltikinin: A new yyotropic tryptophyllin-3 peptide Isolated from the skin secretion of the purple-sided leaf frog, Phyllomedusa baltea.Toxins.8: 213 (IF=3.030).

8.Yang, N., Li, L., Wu, D., Gao, Y., Xi, X., Zhou, M., Wang, L., Chen, T. and Shaw, C., (2016) Discovery of novel bacterial cell-penetrating Phylloseptins in defensive skin secretions of the south American Hylid frogs, Phyllomedusa duellmani and Phyllomedusa coelestis. Toxins. 8: 255 (IF=3.030).

9.Gao, Y.,Zhao, L., Sheng, M., Wang, M., Zhao, C., (2014) Determination of the contents of four7 fatty acids in soybean oil for injection by GC-MS and GC. Journal of Shenyang PharmaceuticalUniversity, 30 (9): 704-708.

10.Gao, Y., Zhao, L., Sheng, M., Wang, M., Zhao, C., (2014) Studying on the compatibility of soybean oil for injection and high density polyethylene bottles.West China Journal of Pharmaceutical Sciences. 29 (2): 164-166.

11.Sheng, M., Zhao, L., Gao, Y., Wang, M., Zhao, C., (2014) Compatibility of medium-chain triglycerides and HDPE bottles. Journal of Shenyang Pharmaceutical University. 30 (3): 211-216.

12.Sheng, M., Zhao, L., Gao, Y., Wang, M., Zhao, C., (2014) Identification and determination of medium- chain triglycerides. West China Journal of Pharmaceutical Sciences. 29 (3): 323-325.

13.Lin, Q., Cao, Y,. Gao, Y., Shen, C., Zhao, C., (2012) Determination of four kind of metal elements Pernyi (Hua) diels by FAAS. Chinese Journal of spectroscopy laboratory. 29 (6): 3609-3613.

14.Lin, Q., Li, J.,Gao, Y., Cao, Y., (2011) Method comparison of the determination of Caffeine in Tankejing Powder. Chinese Journal of Ethnomedicine and ethnopharmacy. 3:37-38

联系方式

Email：gaoyitianwzu@outlook.com

Tel：13625771762