个人简介
邹慧熙 男，博士，教授，硕士生导师，1984年1月生于浙江永嘉，2006年在浙江大学获食品科学与工程学士学位，随后保送直攻博，并于2011年获食品科学博士学位，期间分别于2007年和2009年赴德国杜塞尔多夫大学和马尔堡大学生物药物与生物技术研究所进行博士生联合培养，是温州市“551新世纪人才工程”第二层次培养对象，现任生物系副主任、生物技术专业负责人。
长期致力于藻类生理生态学和次级代谢方面的研究工作；主持国家自然科学基金、浙江省自然科学基金等国家、省部级项目近10项；以通讯作者或第一作者在Applied Microbiology and Biotechnology、Journal of Natural Products、Organic & Biomolecular Chemisty、Aquaculture、Science China-Life Sciences、Ecotoxicology and Environmental Safety等国内外期刊发表研究论文10余篇，为Ecotoxicology and Environmental Safety、Journal of Applied Phycology等SCI期刊的审稿人。
主要研究方向
藻类生理生态学、藻类次级代谢途径和调控、生物活性物质的酶化学合成。
主要社会兼职
2019年-至今，浙江省食品学会青年委员会委员
发表论文
2006-2010
1.Edyta Stec, Nicola Steffan, Anika Kremer,Huixi Zou, Xiaodong Zheng, Shu-Ming Li*. 2008. Two lysine residues are responsible for the enzymatic activities of indole prenyltransferases from fungi.ChemBioChem. 9(13): 2055-2058.
2.Hui-Xi Zou, Xiaodong Zheng, Shu-Ming Li*. 2009. Substrate promiscuity of the cyclic dipeptide prenyltransferases fromAspergillus fumigatus.Journal of Natural Products. 72(1): 44-52.
3.Hui-Xi Zou, Xiu-Lan Xie, Uwe Linne,Xiao-Dong Zheng,Shu-Ming Li*. 2010. SimultaneousC7- and N1-prenylation of cyclo-L-Trp-L-Trp catalyzed by a prenyltransferase fromAspergillus oryzae.Organic & Biomolecular Chemisty. 8(13): 3037-3044.
2011-2015
4.Hui-Xi Zou, Xiulan Xie, Xiao-Dong Zheng, Shu-Ming Li*. 2011. The tyrosine O-prenyltransferase SirD catalyzes O-, N-,and C-prenylation.Applied Microbiology Biotechnology. 89(5): 1443–1451.
5.Hui-Xi Zou, Nan Li, Li-Hua Wang, Ping Yu, Xiu-Feng Yan*. 2014.Equilibrium and Kinetic Studies of Cd2+ Biosorption by the Brown AlgaeSargassum fusiforme.PLoS ONE. 9(4): e95242.
6.Hui-Xi Zou, Qiu-Ying Pang, Li-Dong Lin, Ai-Qin Zhang, Nan Li, Yan-Qing Lin, Lu-Min Li, Qin-Qin Wu, Xiu-Feng Yan*.2014. Behavior of the Edible SeaweedSargassum fusiforme to Copper Pollution: Short-Term Acclimation and Long-Term Adaptation.PLoS ONE. 9(7): e101960.
7.Hui-Xi Zou, Qiu-Ying Pang, Ai-Qin Zhang, Li-Dong Lin, Nan Li, Xiu-Feng Yan*. 2015.Excess copper induced proteomic changes in the marine brown algae Sargassum fusiforme.Ecotoxicology and Environmental Safety. 111: 271-280.
8.Aiqin Zhang, Tao Xu, Huixi Zou, Qiuying Pang*. 2015.Comparative proteomic analysis provides insight into cadmium stress responses in brown algaeSargassum fusiforme.Aquatic Toxicology. 163:1-15.
9.Carsten Wunsch,Hui-Xi Zou, Uwe Linne, Shu-Ming Li*. 2015. C7-prenylation of tryptophanyl and O-prenylation of tyrosyl residues in dipeptides by anAspergillus terreus prenyltransferase.Applied Microbiology and Biotechnology. 99:1719-1730.
2016-2020
10.Wei-Guo Qian, Nan Li, Li-Dong Lin, Tao Xu, Xu Zhang, Li-Hua Wang,Hui-Xi Zou*, Ming-Jiang Wu*, Xiu-Feng Yan. 2016. Parallel analysis of proteins in brown seaweedSargassum fusiforme responding to hyposalinity stress.Aquaculture. 465: 189-197.
11.Peichao Chen, Dan He, Ya Zhang, Shanshan Yang, Liujun Chen, Shengqin Wang,Huixi Zou, Zhiyong Liao, Xu Zhang*, Mingjiang Wu*. 2017.Sargassum fusiforme polysaccharides activate antioxidant defense by promoting Nrf2-dependent cytoprotection and ameliorate stress insult during aging.Food & Function. 7: 4576-4588.
12.Yanjing Zheng, Xiuna Wang, Xiaoling Zhang, Wei Li, Gang Liu,Shihua Wang, Xiufeng Yan,Huixi Zou*, Wen-Bing Yin*.2017. COP9 signalosome subunit PfCsnE regulates secondary metabolism and conidial formation inPestalotiopsis fici. Science China-Life Sciences.60(6): 656-664.
13.Yanjing Zheng, Ke Ma, Haining Lyu, Ying Huang, Hongwei Liu, Ling Liu, Yongsheng Che, Xingzhong Liu,Huixi Zou, Wen-Bing Yin*. 2017. Genetic Manipulation of the COP9 Signalosome Subunit PfCsnE Leads to the Discovery of Pestaloficins inPestalotiopsis fici.Oganic Letters. 19 (17), 4700-4703.
14.Peng Zhang, Xiuna Wang, Aili Fan, Yanjing Zheng, Xingzhong Liu, Shihua Wang,Huixi Zou, Berl R. Oakley, Nancy P. Keller, Wen-Bing Yin*. 2017. A cryptic pigment biosynthetic pathway uncovered by heterologous expression is essential for conidial development inPestalotiopsis fici.Molecular Microbiology. 105: 469-483.
15.Shengqin Wang, Nan Li,Huixi Zou, Mingjiang Wu*. 2018. Gut microbiome-based secondary metabolite biosynthetic gene clusters detection in Parkinson’s disease. Neuroscience Letters. 696: 93-98.
16.Yonghua Zhang, Shengqin Wang, Weiguo Qian, Yijian Shi, Nan Li,Xiufeng Yan,Huixi Zou*, Mingjiang Wu*. 2019. Characterization of the complete chloroplast genome of Sargassum fusiforme and its phylogenomic position within phaeophyceae.Mitochondrial DNA Part B. 4:2, 3258-3259.
17.Shengqin Wang, Na Li, Nan Li,Huixi Zou*, Mingjiang Wu*. 2019. A Comparative Analysis of Biosynthetic Gene Clusters in Lean and Obese Humans.BioMed Research International. 2019: 6361320.
18.Shengqin Wang, Zhihong Zheng,Huixi Zou, Nan Li, Mingjiang Wu*. 2019. Characterization of the secondary metabolite biosynthetic gene clusters in archaea. Computational Biology and Chemistry. 78: 165-169.
19.Xiaoli Liang, Yinliang Yang, Chao Zou, Wei Chen,Hui-Xi Zou*, Yun Yang*. 2020. Au decahedra withhigh yield for the improved synthesis of Au nanobipyramids. Colloids and Surfaces A. 597: 124749.
科研课题
1.重金属污染对羊栖菜代谢的毒性机制研究，温州市重点科技创新团队项目，8万元，2012.1-2014.12，主持
2.重金属污染影响褐藻羊栖菜代谢的毒性机制解析，国家自然科学基金面上项目，85万元，2013.1-2016.12，参与
3.典型重金属污染物对温州羊栖菜毒理效应的代谢组学研究，浙江省自然科学基金青年项目，5万元，2013.1-2015.12，主持
4.褐藻羊栖菜重金属代谢的毒性机制研究，浙江省钱江人才计划项目，5万元，2013.1-2014.12，主持
5.海洋细菌还原铬基因与耐盐特性的关联研究，国家自然科学基金青年项目，23万元，2014.1-2016.12，参与
6.褐藻羊栖菜重金属代谢的毒性机制研究，留学人员科技活动项目择优资助省小额资助，2万元，2014.1-2016.12，主持
7.南美白对虾细菌性肝胰腺坏死症的病原分析及早期诊断，浙江省公益计划项目（协同创新），20万元，2015.1-2016.12，参与
8.褐藻羊栖菜耐受低渗胁迫的代谢应答机制解析，国家自然科学基金青年项目，23万元，2015.1-2017.12，主持
9.表观遗传调控真菌天然产物的发现及生物合成研究，真菌学国家重点实验室开放课题，15万元，2015.1-2016.12，主持
10.羊栖菜新品种选育和推广应用，国家星火计划项目，100万元，2015.1-2017.12，参与
11.基于熵的阿尔兹海默病miRNA表达谱分布特征研究及相关平台构建，浙江省自然科学基金青年项目，5万元，2016.1-2018.12，参与
12.高氧处理调控采后灵芝三萜类物质代谢机理的研究，国家自然科学基金面上项目，78万元，2016.1-2019.12，参与
13.硅藻适应铁限制海区环境机制中铁载体的作用解析，国家自然科学基金面上项目，75.6万元，2017.1-2020.12，主持
14.重要养殖藻类生态适应性与安全性评价，国家重点研发计划蓝色粮仓科技创新专项课题，295万元，2018.12-2022.12，参与
15.褐藻羊栖菜聚酮肽类活性成分挖掘及其酶化学合成开发，浙江省公益研究计划项目，10万元，2019.1-2021.12，主持
专著、获奖情况及个人荣誉
1.2014年入选《温州市“551人才工程”》第三层次培养
2.2016年入选《温州市“551人才工程”》第二层次培养
承担的主要课程
基因工程，仪器分析、营养学、生物专业英语
联系电话 18267789098
电子邮箱 zjuzhx@wzu.edu.cn,zjuzhx@zju.edu.cn
